Opening Plenary A Global Movement to End RHD Yas Grand 1,2,3
10:30 – 11:15
Break / Poster Sessions
11:15 – 12:15
Symposia
Identifying and Developing Strep A Vaccine Candidates Yas Grand 4
Identifying and Developing Strep A Vaccine Candidates
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 4
Chair(s)
Emmy Okello
Uganda Heart Institute
Luiza Guilherme
Univeristy of São Paulo
Presentations
The Landscape of Vaccine Candidates
Andrew Steer (Murdoch Children’s Research Institute)
SAVAC
Jerome Kim (International Vaccine Institute)
ASAVI
Alma Fulurija (University of Western Australia, Telethon Kids Institute)
Molecular Epidemiology of Strep Infection: Insights to Better Tackle Rheumatic Heart Disease Yas Grand 5
Molecular Epidemiology of Strep Infection: Insights to Better Tackle Rheumatic Heart Disease
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 5
Chair(s)
Nikki Moreland
University of Auckland
Presentations
The rheumatogenic emm-type concept in the light of global epidemiological data
Josh Osowicki (Murdoch Children’s Research Institute)
Studies on transmission in endemic regions
Joselyn Rwebembera (Uganda Heart Institute)
Whole genome sequencing of Strep A: Informing regional transmission pathways through longitudinal genomic epidemiology
Mark Davies (University of Melbourne)
Housing, Environment, and Health: New, Novel, and Next in Primordial Prevention Yas Grand 1,2,3
Housing, Environment, and Health: New, Novel, and Next in Primordial Prevention
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 1,2,3
Chair(s)
Maylene Shung-King
University of Cape Town
Liesl Zühlke
University of Cape Town
Presentations
State of the Science and Strength of the Evidence, Patient Voice. Implementation, Dissemination, Cost. Moving past ‘a disease of poverty’ to understand specific environmental risk factors for ARF and RHD development
Rosemary Wyber (Telethon Kids Institute)
Understanding GAS transmission pathways and opportunities to intervene. Modern insights into the pathogenesis, epidemiology, and control of GAS infections
Shiranee Sriskandan (Imperial College London)
How much progress have we made? Novel insights into the design and implementation of primordial prevention strategies
Anna Ralph (Menzies School of Health Research)
Remote community laundries – A shared vision for improved health and social impact
Le Smith (Heart Foundation of Australia)
Elizabeth Morgan-Brett (Aboriginal Investment Group)
Improving Access to Catheter-Based Therapies Yas Stada 1,2
Improving Access to Catheter-Based Therapies
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Stada 1,2
Chair(s)
Ganesan Karthikeyan
All India Institute of Medical Sciences
Sajidah Khan
University of Kwazulu-Natal
Presentations
Access to catheter-based therapies for RHD, capacity building and training for catheter therapies in LMICs (Magdi Yacoub lecture for advances in surgery for RHD)
Krishna Kumar (Amrita Institute of Medical Sciences and Research Centre)
Cost effectiveness: Aggressive preventive measures to surgical vs catheter based interventions
Craig Sable (Children’s National Hospital in Washington, D.C)
12:15 – 13:30
Lunch & Poster Tour
LUNCH SYMPOSIUM - Sponsored by the Snow Foundation (12:15-13:15) How Philanthropy Can Support Collaborative Efforts to Progress Ending RHD Yas Grand 4
13:30 – 14:30
Symposia
Diagnostics and Biomarkers: How Far Along Are We? Yas Grand 5
Diagnostics and Biomarkers: How Far Along Are We?
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Chair(s)
Tom Parks
Imperial College London
Anna Norrby-Teglund
Karolinska Institutet
Presentations
Biomarkers at the level of the valve
Arun Bandyopadhyay (Gujarat Biotechnology University)
The Potential of Antibody Biomarkers to Improve Rheumatic Fever Diagnosis
Nikki Moreland (University of Auckland)
Putting all in clinical context of Jones criteria and potential role of AI
Andrea Beaton (Cincinnati Children’s Hospital)
Pragmatic Vs Perfect Primary Prevention Programmes Yas Grand 1,2,3
Pragmatic Vs Perfect Primary Prevention Programmes
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 1,2,3
Chair(s)
Asha Bowen
Perth Children’s Hospital
Telethon Kids Institute
Joselyn Rwebembera
Uganda Heart Institute
Presentations
How do we address the issue of sub-clinical infections? (Edward Kaplan lecture for contribution to streptococcal biology)
Ana Mocumbi (Universidade Eduardo Mondlane)
Overview of Primary Prevention and the Dual Importance of Skin and Throat Infections
Asha Bowen (Perth Children’s Hospital and Telethon Kids Institute)
The Opportunity for Strep A Point-of-Care Testing to prevent ARF
Bernadette Wong (Telethon Kids Institute)
The Community Voice on Healthy Skin and Primary Prevention of ARF 2.5
Tracy McRae (University of Western Australia)
Stephanie Enkel (University of Western Australia)
What can we learn about primary prevention from SPYCATS?
Edwin Armitage (London School of Hygiene and Tropical Medicine)
Partnering with the community to support co-design of sore throat program
Joselyn Rwebembera (Uganda Heart Institute)
Innovations in Cardiac Interventions Yas Stada 1,2
Innovations in Cardiac Interventions
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Stada 1,2
Chair(s)
Geu-Ru Hong Yonsei University
Emmy Okello
Uganda Heart Institute
Presentations
Need for innovations in valve therapy Mpiko Ntsekhe (University of Cape Town)
Evolving surgical techniques for rheumatic mitral valve disease
Bhagawan Koirala (Manmohan Cardiothoracic Vascular and Transplant Center)
Need for catheter registries in LMIC
Krishna Kumar (Amrita Institute of Medical Sciences and Research Centre)
Imaging-based Criteria for Identifying Suitable Candidates for Percutaneous Mitral Valvuloplasty
Maria Do Carmo Nunes (Federal University of Minas Gerais)
14:30 – 15:15
Break / Poster Sessions
15:15 – 16:15
Symposia
Technical Advances for Strep A Vaccine Development Yas Grand 4
Technical Advances for Strep A Vaccine Development
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 4
Chair(s)
Jonathan Carapetis
Telethon Kids Institute
Presentations
Development and validation of multiplexed electrochemiluminescent assays for the measurement of human immunoglobulin antibodies to group Strep antigens
Alma Fulurija (University of Western Australia, Telethon Kids Institute)
Characterization of a 5-plex assay to measure Streptococcus pyogenes IgA and IgG in oral fluid samples
Fatoumata Camara (London School of Hygiene and Tropical Medicine)
Systems serology identifies key correlates of Group A Streptococcus killing to inform vaccine development
Reuben McGregor (University of Auckland)
Adjuvant selection is critical to improve vaccine protection against GAS colonisation and invasive disease in animal models
Tania Rivera-Hernandez (Cátedras Conacyt)
Implementing Artificial Intelligence for Diagnosis of Rheumatic Disease: A Field Study
Kelsey Brown (Children’s National Hospital in Washington, D.C)
Streptococcal Mechanisms: Novel Models and New Insights into Acute Rheumatic Fever and Rheumatic Heart Disease Yas Grand 5
Streptococcal Mechanisms: Novel Models and New Insights into Acute Rheumatic Fever and Rheumatic Heart Disease
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 5
Chair(s)
Tom Parks Imperial College London
Najma Latif
Imperial College London
Presentations
Establishment of a fully characterised model of Rheumatic Heart Disease
Natkunam Ketheesan (University of New England)
What can models teach us about host-pathogen interaction in rheumatic pathogenesis
Shiranee Sriskandan (Imperial College, London)
Prospects for ex-vivo models for rheumatic heart disease
Najma Latif (Imperial College London)
Start Early and Aim High: Advances in Secondary Antibiotic Prophylaxis Yas Grand 1,2,3
Start Early and Aim High: Advances in Secondary Antibiotic Prophylaxis
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 1,2,3
Chair(s)
Sulafa Ali
University of Khartoum
Joseph Kado
Telethon Kids Institute
Presentations
State of the Science and Strength of the Evidence: Patient Voice
Vicki Wade (Heart Foundation of Australia)
Journey on Penicillin Work
Laurens Manning (University of Western Australia)
Using pharmacokinetic modelling to understand and inform clinical trials for secondary prophylaxis of RHD Abdullah Al Shafi Majumder (Bangladesh Specialized Hospital Ltd)
“Hurts Less, Lasts Longer”: Experiences of young people receiving high-dose subcutaneous infusions of benzathine penicillin G to prevent rheumatic heart disease
Julie Bennett (University of Otago)
Julie Cooper (University of Otago)
Risk Stratification Models for Valvular Surgery and Interventions Yas Stada 1,2
Risk Stratification Models for Valvular Surgery and Interventions
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Stada 1,2
Chair(s)
Emmy Okello
Uganda Heart Institute
Presentations
Surgical risk stratification for patients with RHD
Krishna Kumar (Amrita Institute of Medical Sciences and Research Centre)
Role of Heart Valve Team: Starting discussion with a case
Geu-Ru Hong (Yonsei University)
Preoperative Left Ventricular Dysfunction Is a Risk Factor for Late Death in Paediatric Patients after Rheumatic Heart Disease Surgery for Isolated Aortic Valve Disease
Hilary Hardefeldt (Starship Children’s Hospital)
16:30 – 17:30
Opening Ceremony Yas Grand 1,2,3
FRIDAY, 3 NOVEMBER
Strep A Vaccines
Pathogenesis & Other Biological Insights
Clinical Presentation & Contemporary Management
Tertiary Care & Surgery
8:00 – 9:00
BREAKFAST SESSION - Sponsored by Edwards Foundation Every Heartbeat Matters: What More Can We Do to Impact Underserved RHD Patients? Yas Grand 4
9:00 – 10:30
Symposia
Equitable Access to Strep A Vaccines: From Testing to Implementation Yas Grand 4
Equitable Access to Strep A Vaccines: From Testing to Implementation
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 4
Chair(s)
Shiranee Sriskandan
Imperial College London
Presentations
Animal and human challenge models
Josh Osowicki (Murdoch Children’s Research Institute)
Considerations for accelerating equitable access to Strep A vaccines globally
Thomas Cherian (MMGH Consulting)
Post-licensure studies
Jerome Kim (International Vaccines Initiative)
The Importance of Community Engaged Design for Clinical Trial Planning and Execution
Andrea Beaton (Cincinnati Children’s Hospital)
Host-Focused Mechanisms Leading to Acute Rheumatic Fever and Rheumatic Heart Disease Yas Grand 5
Host-Focused Mechanisms Leading to Acute Rheumatic Fever and Rheumatic Heart Disease
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 5
Chair(s)
Anna Norrby-Teglund
Karolinska Institutet
Presentations
What do we know about molecular mimicry and RHD?
Madeleine Cunningham (University of Oklahoma Health Sciences Center)
Virulence potential of streptococcal M and M-like surface proteins
Pierre Smeesters (Hôpital Universitaire des Enfants Reine Fabiola)
Role of Group A carbohydrate and other glycans
Nina van Sorge (Amsterdam UMC)
RHD and host genetics
Tom Parks (Imperial College London)
The Know-Do Gap: Implementing and Disseminating Best Practices Yas Grand 1,2,3
The Know-Do Gap: Implementing and Disseminating Best Practices
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 1,2,3
Chair(s)
Sulafa Ali
University of Khartoum
Krishna Kumar
Amrita Institute of Medical Sciences and Research Centre
Presentations
Keynote address (Padmavati – Roy – Bhatia – Tandon lecture for Global Influence in the Field of RHD): Liesl Zühlke University of Cape Town
Emmy Okello
Uganda Heart Institute
Oyoo Charles Akiya
Ministry of Health of Uganda
Poonam Pal
Ministry of Health and Medical Services of Fiji
Management of severe rheumatic mitral and aortic regurgitation in the young Nigel Wilson (Starship Children’s Hospital)
More in Medical Therapies for Rheumatic Heart Disease Yas Stada 1,2
More in Medical Therapies for Rheumatic Heart Disease
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Stada 1,2
Chair(s)
Bo Remenyi
Royal Darwin Hospital
Presentations
Anticoagulation for atrial fibrillation in RHD after INVICTUS (Bongani Mayosi lecture for leadership in clinical trials)
Ganesan Karthikeyan (All India Institute of Medical Sciences)
Medical management of heart failure
Joselyn Rwebembera (Uganda Heart Institute)
Care for RHD-affected young women
Ana Mocumbi (Universidade Eduardo Mondlane)
New Formulations
Laurens Manning (University of Western Autralia)
Novel therapeutics for ARF and RHD: Lessons from HCQ4ARF study
Rachel Webb (University of Auckland)
10:30 – 11:15
Break / Poster Sessions
11:15 – 12:15
Plenary Priority Setting for Strep A Vaccines Yas Grand 1,2,3
12:15 – 13:30
Lunch & Poster Tour
13:30 – 14:30
Symposia
Vaccines Safety Yas Grand 4
Vaccines Safety
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 4
Chair(s)
Shiranee Sriskandan
Imperial College London
Presentations
The importance of safety in Strep A: Key considerations
Shiranee Sriskandan (Imperial College London)
The risk-benefit balance in vaccine development from the perspective of people living with RHD
Erini Tokarua (Cure Kids)
Vaccines Hesitancy and Key Considerations for Development
Katie Attwell (University of Western Australia)
Safety assessment pathways for Streptococcus pyogenes vaccines – learning from history
Andrew Steer (Murdoch Children’s Research Institute)
A plasma protein biomarker for ARF
Emmy Okello (Uganda Heart Institute)
The Neglected Stage of a Neglected Disease: Insights and Innovations for Tackling Rheumatic Fever Yas Grand 5
The Neglected Stage of a Neglected Disease: Insights and Innovations for Tackling Rheumatic Fever
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Chair(s)
Jagat Narula
World Heart Federation
Presentations
Basic Science: New ways of diagnosing RF
Anna Ralph (Menzies School of Health Research)
Clinical Research: Simplified criteria for RHD
Bo Remenyi (Royal Darwin Hospital)
Silent Acute Rheumatic Fever Revealed by Handheld Echocardiography
Sulafa Ali (University of Khartoum)
Clinical Decision-making for Heart Failure in RHD: ARF, Worsening Disease, or else?
Anita Saxena (Pt. BD Sharma University of Health Sciences)
Community Action to Drive Access to Catheter and Surgery Yas Stada 1,2
Community Action to Drive Access to Catheter and Surgery
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Stada 1,2
Chair(s)
Ana Mocumbi
Universidade Eduardo Mondlane
Presentations
Establishing Valvular Heart Disease Programs in Developing World: Why and How?
Mohammad Abdelghani (Al-Azhar University)
Improving Access to Cardiac Surgery for the Six Billion Without
Dominique Vervoort (University of Toronto)
Impact of Patient support groups on care
Flavia Baturine Kamalembo (Uganda Heart Institute)
Understanding the lived experience and its impact
Anu Gomanju (NCDI Poverty Network, Kathmandu Institute of Child Health and Global ARCH)
14:30 – 15:15
Break / Poster Sessions
15:15 – 16:15
Plenary Establishing Integrated National Rheumatic Heart Disease Programmes Yas Grand 1,2,3
16:15 – 17:30
Symposia
The Latest in Strep A Vaccine Development (Abstract Session) Yas Grand 4
The Latest in Strep A Vaccine Development
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Grand 4
Chair(s)
Alma Fulurija
University of Western Australia
Telethon Kids Institute
Presentations
Back to the future: Lessons from early twentieth century scarlet fever outbreaks for modern vaccine development
Josh Osowicki (Murdoch Children’s Research Institute)
Development of a Peptide-based vaccine to prevent rheumatic heart disease
Michael Good (Griffith University)
Facilitating Strep A Vaccine Development for Aotearoa New Zealand
Nikki Moreland (University of Auckland)
Platform for the recombinant production of group A streptococcus gylcoconjugate vaccines
Helge Dorfmuller (University of Dundee)
A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils
Manisha Pandey (University of Griffith)
SPECIAL SESSION Voices of RHD: Learning from Lived Experiences Yas Grand 1,2,3
Voices of RHD: Learning from Lived Experience
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Grand 1,2,3
Chair(s)
Vicki Wade
Heart Foundation of Australia
Anu Gomanju
NCDI Poverty Network
Kathmandu Institute of Child Health
Global ARCH
Presentations
Subjective wellbeing among rheumatic heart disease patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: Observational cross-sectional study
Henok Tadele (Addis Ababa University)
Increasing knowledge and awareness for the prevention of rheumatic fever and rheumatic heart disease through school-based education activities in an endemic country
Keila Jamal (Mozambique Institute for Health Education and Research)
Rheumatic heart disease patient voices from the Pacific: A mixed methods study from Fiji
Jyotishna Mani (Cure Kids)
Is Digital Health the Future? Innovations and Opportunities in Rheumatic Heart Disease Yas Stada 1,2
Is Digital Health the Future? Innovations and Opportunities in Rheumatic Heart Disease
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Stada 1,2
Chair(s)
Andrea Beaton
Cincinnati Children’s Hospital
Presentations
Mobile RHD Registries
Emmy Okello (Uganda Heart Institute)
The Potential of Digital Technology and AI for the Rapid Diagnosis of GAS Pharyngitis
Joselyn Rwebembera (Uganda Heart Institute)
Opportunities and challenges in imaging for RHD
Maria Do Carmo Nunes (Federal University of Minas Gerais)
Delivering equitable and appropriate echocardiography in a multi-ethnic world
Gillian Whalley (University of Otago)
17:45 - 19:00
FILM SCREENING 'Take Heart: Deadly Heart' Yas Grand 1,2,3
SATURDAY, 4 NOVEMBER
Strep A Vaccines
Pathogenesis & Other Biological Insights
Clinical Presentation & Contemporary Management
Tertiary Care & Surgery
9:00 – 10:30
Plenary What Does Rheumatic Heart Disease Research Look Like in 10 Years’ Time? Yas Grand 1,2,3
10:30 – 11:15
Break / Poster Sessions
11:15 – 12:15
Plenary A Global Action Plan for Rheumatic Heart Disease Yas Grand 1,2,3
12:15 – 13:30
Lunch & Poster Tour
13:30 – 14:30
Symposia
Measuring and communicating the value of Strep A vaccines Yas Grand 4
Measuring and communicating the value of Strep A vaccines
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 4
Chair(s)
Anshu Banerjee
World Health Organization
Maylene Shung-King
University of Cape Town
Presentations
The value of vaccination from a health and healthcare perspective Jeffrey Cannon (Telethon Kids Institute)
Building the case for biopharma industry investment in Strep A vaccine development Don Walkinshaw (Shift Health)
Communicating the Value of Group A Streptococcus Vaccine Research and Development: Full Benefits and Innovation
Daniel Tortorice (College of the Holy Cross)
The Epidemiology and Burden of RHD and Other Strep A Diseases: New Insights Yas Grand 5
The Epidemiology and Burden of RHD and Other Strep A Diseases: New Insights
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Chair(s)
Rosemary Wyber
Telethon Kids Institute
Presentations
The global burden of RHD David Watkins (University of Washington)
Epidemiology of bacterial skin infections in primary healthcare in Auckland, New Zealand
Krishtika Mala (University of Otago)
Prevalence of rheumatic heart disease in Senegalese school children: A clinical and echocardiographic screening
Aliou Assane Ngaide (Cheikh Anta DIOP University of Dakar)
The burden of RHD in India: An overview
Rajesh Beniwal (Calendula Healthcare Ltd)
The Importance and Implications of Early Rheumatic Heart Disease Detection and Treatment Yas Grand 1,2,3
The Importance and Implications of Early Rheumatic Heart Disease Detection and Treatment
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 1,2,3
Chair(s)
Liesl Zühlke
University of Cape Town
Presentations
The importance of publishing evidence-based guidelines (Gene Stollerman lecture for advances in research)
Greg Lim (Nature Reviews Cardiology)
All you need to know about the new 2023 World Heart Federation Guidelines for echocardiographic diagnosis of RHD
Joselyn Rwebembera (Uganda Heart Institute)
Updates in the role of secondary antibiotic prophylaxis in latent RHD
Andrea Beaton (Cincinnati Children’s Hospital)
14:30 – 15:30
Closing Ceremony Call to Action on Ending RHD Yas Grand 1,2,3