Strep A Vaccines | Pathogenesis & Other Biological Insights | Clinical Presentation & Contemporary Management | Tertiary Care & Surgery | |
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9:00 – 10:30 |
Opening Plenary A Global Movement to End RHD Yas Grand 1,2,3 A Global Movement to End Rheumatic Heart Disease
Thursday, 2 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 1,2,3
Chair(s)
Jagat Narula Liesl Zühlke Welcome remarks: Tedros Adhanom Ghebreyesus
Presentations
Fighting RHD in the WHO Eastern Mediterranean Region (EMR) – The Challenge, the Response and the Way Forward A Vision to End RHD: Hopes for the WHA Resolution on RF and RHD The Key Role of People Living with Rheumatic Heart Disease Eliminating RHD by 2050: How Many Lives Could Be Saved, and How Much Would It Cost? |
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10:30 – 11:15 |
Break / Poster SessionsPoster Sessions 1-2
Thursday, 2 November
Start time: 10:30 am End time: 11:10 am
E-Poster Area
POSTER SESSION 1 (10:30-10:50)Station 1: Beneficial Effect Of Resveratrol To Inhibit Pathological Myofibroblast Differentiation Of Valvular Interstitial Cell In Experimental Heart Valve Model POSTER SESSION 2 (10:50-11:10)Station 1: Rheumatic Heart Disease (RHD) Burden In Australia: Results And Learnings From Use Of Person-Linked Multi-Jurisdictional Data |
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11:15 – 12:15 |
Symposia |
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Identifying and Developing Strep A Vaccine Candidates Yas Grand 4 Identifying and Developing Strep A Vaccine Candidates
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 4
Track:
Strep A Vaccines
Chair(s)
Emmy Okello Luiza Guilherme Presentations
The Landscape of Vaccine Candidates SAVAC ASAVI |
Molecular Epidemiology of Strep Infection: Insights to Better Tackle Rheumatic Heart Disease Yas Grand 5 Molecular Epidemiology of Strep Infection: Insights to Better Tackle Rheumatic Heart Disease
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Chair(s)
Nikki Moreland Presentations
The rheumatogenic emm-type concept in the light of global epidemiological data Studies on transmission in endemic regions Whole genome sequencing of Strep A: Informing regional transmission pathways through longitudinal genomic epidemiology |
Housing, Environment, and Health: New, Novel, and Next in Primordial Prevention Yas Grand 1,2,3 Housing, Environment, and Health: New, Novel, and Next in Primordial Prevention
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 1,2,3
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Maylene Shung-King Liesl Zühlke Presentations
State of the Science and Strength of the Evidence, Patient Voice. Implementation, Dissemination, Cost. Moving past ‘a disease of poverty’ to understand specific environmental risk factors for ARF and RHD development Understanding GAS transmission pathways and opportunities to intervene. Modern insights into the pathogenesis, epidemiology, and control of GAS infections How much progress have we made? Novel insights into the design and implementation of primordial prevention strategies Remote community laundries – A shared vision for improved health and social impact
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Improving Access to Catheter-Based Therapies Yas Stada 1,2 Improving Access to Catheter-Based Therapies
Thursday, 2 November
Start time: 11:15 am End time: 12:15 pm
Yas Stada 1,2
Track:
Tertiary Care & Surgery
Chair(s)
Ganesan Karthikeyan Sajidah Khan Presentations
Access to catheter-based therapies for RHD, capacity building and training for catheter therapies in LMICs (Magdi Yacoub lecture for advances in surgery for RHD) Cost effectiveness: Aggressive preventive measures to surgical vs catheter based interventions
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12:15 – 13:30 |
Lunch & Poster TourClinical Presentation and Contemporary Management Poster Tour
Thursday, 2 November
Start time: 12:30 pm End time: 1:30 pm
Station 1: Rheumatic Heart Disease In School Attending Nepalese Children: A Descriptive Analysis Of The National Heart Screening Database Chair(s)
Andrea Beaton |
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LUNCH SYMPOSIUM - Sponsored by the Snow Foundation (12:15-13:15) How Philanthropy Can Support Collaborative Efforts to Progress Ending RHD Yas Grand 4 The Snow Foundation Symposium: How philanthropy can support collaborative efforts to progress ending RHD
Thursday, 2 November
Start time: 12:15 pm End time: 1:15 pm
Yas Grand 4
Presentations
Georgina Byron Vicki Wade Gavin Wheaton Bo Remenyi Kenya McAdam Dawn Casey Jonathan Carapetis |
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13:30 – 14:30 |
Symposia |
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Diagnostics and Biomarkers: How Far Along Are We? Yas Grand 5 Diagnostics and Biomarkers: How Far Along Are We?
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Chair(s)
Tom Parks Anna Norrby-Teglund Presentations
Biomarkers at the level of the valve The Potential of Antibody Biomarkers to Improve Rheumatic Fever Diagnosis Putting all in clinical context of Jones criteria and potential role of AI |
Pragmatic Vs Perfect Primary Prevention Programmes Yas Grand 1,2,3 Pragmatic Vs Perfect Primary Prevention Programmes
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 1,2,3
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Asha Bowen Joselyn Rwebembera Presentations
How do we address the issue of sub-clinical infections? (Edward Kaplan lecture for contribution to streptococcal biology) Overview of Primary Prevention and the Dual Importance of Skin and Throat Infections The Opportunity for Strep A Point-of-Care Testing to prevent ARF The Community Voice on Healthy Skin and Primary Prevention of ARF 2.5 What can we learn about primary prevention from SPYCATS? Partnering with the community to support co-design of sore throat program |
Innovations in Cardiac Interventions Yas Stada 1,2 Innovations in Cardiac Interventions
Thursday, 2 November
Start time: 1:30 pm End time: 2:30 pm
Yas Stada 1,2
Track:
Tertiary Care & Surgery
Chair(s)
Geu-Ru Hong Emmy Okello Presentations
Need for innovations in valve therapy Evolving surgical techniques for rheumatic mitral valve disease Need for catheter registries in LMIC Imaging-based Criteria for Identifying Suitable Candidates for Percutaneous Mitral Valvuloplasty |
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14:30 – 15:15 |
Break / Poster SessionsPoster Sessions 3-4
Thursday, 2 November
Start time: 2:30 pm End time: 3:10 pm
POSTER SESSION 3 (14:30-14:50) POSTER SESSION 4 (14:50-15:10) |
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15:15 – 16:15 |
Symposia |
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Technical Advances for Strep A Vaccine Development Yas Grand 4 Technical Advances for Strep A Vaccine Development
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 4
Track:
Strep A Vaccines
Chair(s)
Jonathan Carapetis Presentations
Development and validation of multiplexed electrochemiluminescent assays for the measurement of human immunoglobulin antibodies to group Strep antigens Characterization of a 5-plex assay to measure Streptococcus pyogenes IgA and IgG in oral fluid samples Systems serology identifies key correlates of Group A Streptococcus killing to inform vaccine development Adjuvant selection is critical to improve vaccine protection against GAS colonisation and invasive disease in animal models Implementing Artificial Intelligence for Diagnosis of Rheumatic Disease: A Field Study |
Streptococcal Mechanisms: Novel Models and New Insights into Acute Rheumatic Fever and Rheumatic Heart Disease Yas Grand 5 Streptococcal Mechanisms: Novel Models and New Insights into Acute Rheumatic Fever and Rheumatic Heart Disease
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Chair(s)
Tom Parks Najma Latif Presentations
Establishment of a fully characterised model of Rheumatic Heart Disease What can models teach us about host-pathogen interaction in rheumatic pathogenesis Prospects for ex-vivo models for rheumatic heart disease |
Start Early and Aim High: Advances in Secondary Antibiotic Prophylaxis Yas Grand 1,2,3 Start Early and Aim High: Advances in Secondary Antibiotic Prophylaxis
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 1,2,3
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Sulafa Ali Joseph Kado Presentations
State of the Science and Strength of the Evidence: Patient Voice Journey on Penicillin Work Using pharmacokinetic modelling to understand and inform clinical trials for secondary prophylaxis of RHD “Hurts Less, Lasts Longer”: Experiences of young people receiving high-dose subcutaneous infusions of benzathine penicillin G to prevent rheumatic heart disease |
Risk Stratification Models for Valvular Surgery and Interventions Yas Stada 1,2 Risk Stratification Models for Valvular Surgery and Interventions
Thursday, 2 November
Start time: 3:15 pm End time: 4:15 pm
Yas Stada 1,2
Track:
Tertiary Care & Surgery
Chair(s)
Emmy Okello
Presentations
Surgical risk stratification for patients with RHD Role of Heart Valve Team: Starting discussion with a case Preoperative Left Ventricular Dysfunction Is a Risk Factor for Late Death in Paediatric Patients after Rheumatic Heart Disease Surgery for Isolated Aortic Valve Disease |
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16:30 – 17:30 |
Opening Ceremony Yas Grand 1,2,3 Opening Ceremony
Thursday, 2 November
Start time: 4:30 pm End time: 5:30 pm
Yas Grand 1,2,3
Chair(s)
Daniel Pineiro Jagat Narula Jean-Luc Eisele Liesl Zühlke Dignitaries Welcome: Her.Excellency. Dr. Omniyat Mohamed Al Hajeri Kevin Rudd Anu Gomanju |
Strep A Vaccines | Pathogenesis & Other Biological Insights | Clinical Presentation & Contemporary Management | Tertiary Care & Surgery | |
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8:00 – 9:00 |
BREAKFAST SESSION - Sponsored by Edwards Foundation Every Heartbeat Matters: What More Can We Do to Impact Underserved RHD Patients? Yas Grand 4 Breakfast session: Every Heartbeat Matters: What More Can We Do to Impact Underserved RHD Patients?
Friday, 3 November
Start time: 8:00 am End time: 9:00 am
Yas Grand 4
Presentations
Amanda Fowler |
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9:00 – 10:30 |
Symposia |
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Equitable Access to Strep A Vaccines: From Testing to Implementation Yas Grand 4 Equitable Access to Strep A Vaccines: From Testing to Implementation
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 4
Track:
Strep A Vaccines
Chair(s)
Shiranee Sriskandan Presentations
Animal and human challenge models Considerations for accelerating equitable access to Strep A vaccines globally Post-licensure studies The Importance of Community Engaged Design for Clinical Trial Planning and Execution |
Host-Focused Mechanisms Leading to Acute Rheumatic Fever and Rheumatic Heart Disease Yas Grand 5 Host-Focused Mechanisms Leading to Acute Rheumatic Fever and Rheumatic Heart Disease
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Chair(s)
Anna Norrby-Teglund Presentations
What do we know about molecular mimicry and RHD? Virulence potential of streptococcal M and M-like surface proteins Role of Group A carbohydrate and other glycans RHD and host genetics |
The Know-Do Gap: Implementing and Disseminating Best Practices Yas Grand 1,2,3 The Know-Do Gap: Implementing and Disseminating Best Practices
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 1,2,3
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Sulafa Ali Krishna Kumar Presentations
Keynote address (Padmavati – Roy – Bhatia – Tandon lecture for Global Influence in the Field of RHD): Liesl Zühlke Emmy Okello Oyoo Charles Akiya Poonam Pal Management of severe rheumatic mitral and aortic regurgitation in the young |
More in Medical Therapies for Rheumatic Heart Disease Yas Stada 1,2 More in Medical Therapies for Rheumatic Heart Disease
Friday, 3 November
Start time: 9:00 am End time: 10:30 am
Yas Stada 1,2
Track:
Tertiary Care & Surgery
Chair(s)
Bo Remenyi Presentations
Anticoagulation for atrial fibrillation in RHD after INVICTUS (Bongani Mayosi lecture for leadership in clinical trials) Medical management of heart failure Care for RHD-affected young women New Formulations Novel therapeutics for ARF and RHD: Lessons from HCQ4ARF study |
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10:30 – 11:15 |
Break / Poster SessionsPoster Sessions 5-6
Friday, 3 November
Start time: 10:30 am End time: 11:10 am
E-Poster Area
POSTER SESSION 5 (10:30-10:50) Station 1: Iron Deficiency In Chronic Heart Failure Patients At The University Teaching Hospital In Lusaka, Zambia. POSTER SESSION 6 (10:50-11:10) Station 1: Automated Two-Way Messaging Intervention To Support Secondary Prophylaxis Adherence In Rheumatic Heart Disease
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11:15 – 12:15 |
Plenary Priority Setting for Strep A Vaccines Yas Grand 1,2,3 Priority Setting for Strep A Vaccines
Friday, 3 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 1,2,3
Chair(s)
Liesl Zühlke Jonathan Carapetis Presentations
Strep A vaccines: the view from upstream (James Dale and Edwin Beachey lecture for contribution to vaccines research) Emmy Okello Thomas Cherian Jagat Narula Erini Tokarua Elizabeth Gatumia Anshu Banerjee |
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12:15 – 13:30 |
Lunch & Poster TourTertiary Care and Surgery Poster Tour
Friday, 3 November
Start time: 12:30 pm End time: 1:30 pm
E-Poster Area
Station 1: Long-Term Outcomes Of Rheumatic Aortic Regurgitation After Percutaneous Transmitral Commissurotomy Chair(s)
Dominique Vervoort |
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13:30 – 14:30 |
Symposia |
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Vaccines Safety Yas Grand 4 Vaccines Safety
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 4
Track:
Strep A Vaccines
Chair(s)
Shiranee Sriskandan Presentations
The importance of safety in Strep A: Key considerations The risk-benefit balance in vaccine development from the perspective of people living with RHD Vaccines Hesitancy and Key Considerations for Development Safety assessment pathways for Streptococcus pyogenes vaccines – learning from history A plasma protein biomarker for ARF |
The Neglected Stage of a Neglected Disease: Insights and Innovations for Tackling Rheumatic Fever Yas Grand 5 The Neglected Stage of a Neglected Disease: Insights and Innovations for Tackling Rheumatic Fever
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Jagat Narula Presentations
Basic Science: New ways of diagnosing RF Clinical Research: Simplified criteria for RHD Silent Acute Rheumatic Fever Revealed by Handheld Echocardiography Clinical Decision-making for Heart Failure in RHD: ARF, Worsening Disease, or else? |
Community Action to Drive Access to Catheter and Surgery Yas Stada 1,2 Community Action to Drive Access to Catheter and Surgery
Friday, 3 November
Start time: 1:30 pm End time: 2:30 pm
Yas Stada 1,2
Track:
Tertiary Care & Surgery
Chair(s)
Ana Mocumbi Presentations
Establishing Valvular Heart Disease Programs in Developing World: Why and How? Improving Access to Cardiac Surgery for the Six Billion Without Impact of Patient support groups on care Understanding the lived experience and its impact |
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14:30 – 15:15 |
Break / Poster SessionsPoster Sessions 7-8
Friday, 3 November
Start time: 2:30 pm End time: 3:10 pm
E-Poster Area
POSTER SESSION 7 (14:30-14:50) Station 1: Rheumatic Mitral Repair In Nepal: Early Experience POSTER SESSION 8 (14:50-15:10) Station 1: Rationale And Design Of A Controlled Quasi-Experimental Study Testing The Efficacy Of A Rheumatic Heart Disease Education Program In Babati, Tanzania |
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15:15 – 16:15 |
Plenary Establishing Integrated National Rheumatic Heart Disease Programmes Yas Grand 1,2,3 Establishing Integrated National Rheumatic Heart Disease Programmes
Friday, 3 November
Start time: 3:15 pm End time: 4:15 pm
Yas Grand 1,2,3
Chair(s)
Liesl Zühlke Oyere Onuma Presentations
Dawn Casey Lorraine Anderson Ana Mocumbi Juliet Balderas Amy Sanyahumbi Hicham El-Berri |
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16:15 – 17:30 |
Symposia |
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The Latest in Strep A Vaccine Development (Abstract Session) Yas Grand 4 The Latest in Strep A Vaccine Development
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Grand 4
Chair(s)
Alma Fulurija Presentations
Back to the future: Lessons from early twentieth century scarlet fever outbreaks for modern vaccine development Development of a Peptide-based vaccine to prevent rheumatic heart disease Facilitating Strep A Vaccine Development for Aotearoa New Zealand Platform for the recombinant production of group A streptococcus gylcoconjugate vaccines A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils
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SPECIAL SESSION Voices of RHD: Learning from Lived Experiences Yas Grand 1,2,3 Voices of RHD: Learning from Lived Experience
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Grand 1,2,3
Chair(s)
Vicki Wade Anu Gomanju Presentations
Subjective wellbeing among rheumatic heart disease patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: Observational cross-sectional study Increasing knowledge and awareness for the prevention of rheumatic fever and rheumatic heart disease through school-based education activities in an endemic country Rheumatic heart disease patient voices from the Pacific: A mixed methods study from Fiji Anticoagulation management of postoperative rheumatic heart disease patients in Rwanda Kenya McAdam Henrique Thomas Flavia Baturine Kamalembo Erini Tokarua |
Is Digital Health the Future? Innovations and Opportunities in Rheumatic Heart Disease Yas Stada 1,2 Is Digital Health the Future? Innovations and Opportunities in Rheumatic Heart Disease
Friday, 3 November
Start time: 4:15 pm End time: 5:30 pm
Yas Stada 1,2
Track:
Clinical Presentation & Contemporary Management
Track:
Tertiary Care & Surgery
Chair(s)
Andrea Beaton Presentations
Mobile RHD Registries The Potential of Digital Technology and AI for the Rapid Diagnosis of GAS Pharyngitis Opportunities and challenges in imaging for RHD Delivering equitable and appropriate echocardiography in a multi-ethnic world |
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17:45 - 19:00 |
FILM SCREENING 'Take Heart: Deadly Heart' Yas Grand 1,2,3 Film Screening: ‘Take Heart: Deadly Heart’
Friday, 3 November
Start time: 5:45 pm End time: 7:00 pm
Yas Grand 1,2,3
Chair(s)
Introduced by: Viki Wade |
Strep A Vaccines | Pathogenesis & Other Biological Insights | Clinical Presentation & Contemporary Management | Tertiary Care & Surgery | |
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9:00 – 10:30 |
Plenary What Does Rheumatic Heart Disease Research Look Like in 10 Years’ Time? Yas Grand 1,2,3 Think Tank: What Does Rheumatic Heart Disease Research Look Like in 10 Years’ Time?
Saturday, 4 November
Start time: 9:00 am End time: 10:30 am
Yas Grand 1,2,3
Chair(s)
Jagat Narula Shahryar Sheikh Presentations
View from the inside: What are the current strengths and weaknesses of research in ARF and RHD? How do we make the most of the next decade? View from the outside: How do we maximise the benefits of research for ARF and RHD patients? How do we make the most of the next decade? Anna Ralph Tom Parks Emmy Okello Michael Baker
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10:30 – 11:15 |
Break / Poster SessionsPoster Sessions 9-10
Saturday, 4 November
Start time: 10:30 am End time: 11:10 am
E-Poster Area
POSTER SESSION 9 (10:30-10:50) Station 1: Maternal And Fetal Outcomes Of Per Cutaneous Balloon Mitral Valvuloplasty In Rheumatic Heart Disease(Pbmv) During Pregnancy POSTER SESSION 10 (10:50-11:10) Station 1: A Partnership Of Clinical Excellence And Cultural Safety |
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11:15 – 12:15 |
Plenary A Global Action Plan for Rheumatic Heart Disease Yas Grand 1,2,3 A Global Action Plan for Rheumatic Heart Disease
Saturday, 4 November
Start time: 11:15 am End time: 12:15 pm
Yas Grand 1,2,3
Chair(s)
Liesl Zühlke Andrew Steer Presentations
Emmy Okello Ivor Benjamin Anu Gomanju Asha Bowen David Milan Key considerations for the development of a Global Action Plan |
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12:15 – 13:30 |
Lunch & Poster TourPathogenesis and Strep A Vaccines Poster Tour
Saturday, 4 November
Start time: 12:30 pm End time: 1:30 pm
E-Poster Area
Station 1: Rapid Molecular Testing Aids Timely Diagnosis Of Strep A Infection In New Zealand Children With Acute Rheumatic Fever Chair(s)
Tom Parks |
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13:30 – 14:30 |
Symposia |
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Measuring and communicating the value of Strep A vaccines Yas Grand 4 Measuring and communicating the value of Strep A vaccines
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 4
Track:
Strep A Vaccines
Chair(s)
Anshu Banerjee Maylene Shung-King Presentations
The value of vaccination from a health and healthcare perspective Building the case for biopharma industry investment in Strep A vaccine development Communicating the Value of Group A Streptococcus Vaccine Research and Development: Full Benefits and Innovation |
The Epidemiology and Burden of RHD and Other Strep A Diseases: New Insights Yas Grand 5 The Epidemiology and Burden of RHD and Other Strep A Diseases: New Insights
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 5
Track:
Pathogenesis & Other Biological Insights
Chair(s)
Rosemary Wyber
Presentations
The global burden of RHD Epidemiology of bacterial skin infections in primary healthcare in Auckland, New Zealand Prevalence of rheumatic heart disease in Senegalese school children: A clinical and echocardiographic screening The burden of RHD in India: An overview |
The Importance and Implications of Early Rheumatic Heart Disease Detection and Treatment Yas Grand 1,2,3 The Importance and Implications of Early Rheumatic Heart Disease Detection and Treatment
Saturday, 4 November
Start time: 1:30 pm End time: 2:30 pm
Yas Grand 1,2,3
Track:
Clinical Presentation & Contemporary Management
Chair(s)
Liesl Zühlke Presentations
The importance of publishing evidence-based guidelines (Gene Stollerman lecture for advances in research) All you need to know about the new 2023 World Heart Federation Guidelines for echocardiographic diagnosis of RHD Updates in the role of secondary antibiotic prophylaxis in latent RHD |
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14:30 – 15:30 |
Closing Ceremony Call to Action on Ending RHD Yas Grand 1,2,3 Closing Ceremony: Call to Action on Ending RHD
Saturday, 4 November
Start time: 2:30 pm End time: 3:30 pm
Yas Grand 1,2,3
Chair(s)
Jagat Narula Liesl Zühlke Presentations
Vaccines track action points Pathogenesis track action points Clinical presentation and contemporary management track action points Tertiary care and surgery track action points Translating the call to local action: reflections on Pakistan Reflections and WHF call to action |